htpX

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cytoplasmic membrane-associated protease

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to htpX

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: qRT-PCR and MIC testing
Drug Classes: paromomycin
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System.

PMID 27021319 · 2016

Rifampin potentiates the activity of 4,5-linked aminoglycosides against Pseudomonas aeruginosa by targeting the AmgRS envelope stress-response two-component system, which reduces the expression of resistance genes such as htpX, yccA, and mexXY.

Gene Information

Gene Name: htpX
Allele: htpX
Encodes: cytoplasmic membrane-associated protease
Source Database: Reslit
Confers Resistance To: paromomycin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: qRT-PCR and MIC testing

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htpX

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htpX

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