hupA

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undecaprenyl pyrophosphate phosphatase and phosphatidylglycerol phosphate phosphatase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to hupA

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: mutant analysis and complementation
Drug Classes: polymyxin b
Organisms: Helicobacter pylori
Papers: 1
Databases: Reslit

Papers1

HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach.

PMID 31487328 · 2019

HupA is essential for H. pylori colonization of the stomach and contributes to resistance against polymyxin B.

Gene Information

Gene Name: hupA
Allele: hupA
Encodes: undecaprenyl pyrophosphate phosphatase and phosphatidylglycerol phosphate phosphatase
Source Database: Reslit
Confers Resistance To: polymyxin b
Organisms Tested In: • Helicobacter pylori
Validation Method: mutant analysis and complementation

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hupA

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hupA

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