Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ireB

Ser/Thr kinase substrate

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ireB

Browse AMR rules for ireB

Overview

Mechanism: impairs cephalosporin resistance
Drug Classes: cephalosporins
Organisms: Enterococcus faecalis
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D50A	-	impairs cephalosporin resistance	Enterococcus faecalis	cephalosporins	Reslit	Candidate

Papers1

1

IreB, a Ser/Thr kinase substrate, influences antimicrobial resistance in Enterococcus faecalis.

PMID 24080657 · 2013

Mutation Information

Protein Change: D50A
Organisms: Enterococcus faecalis
Confers Resistance To: cephalosporins
Effect on Function: impairs cephalosporin resistance
Validation Method: whole-genome resequencing and susceptibility assays
Source Database: Reslit