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Browse Genesiri

iri

monooxygenase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to iri

Browse AMR rules for iri

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: phageome analysis
Drug Classes: rifampicin, rifamycins, RIFAMPIN
Organisms: Rhodococcus, Nocardia cyriacigeorgica, Prescottella equi
Geographic Location: China, Saudi Arabia|Arctium fruticosum rhizosphere
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Papers3

1

Functional analysis of bacterial genes accidentally packaged in rhizospheric phageome of the wild plant species Abutilon fruticosum.

PMID 37680975 · 2023

The study identified several antibiotic resistance genes (ARGs) accidentally packaged in the phageome of Abutilon fruticosum, including soxR, parY mutant, arr-1, iri, AAC(3)-Ic, and oleC, which confer resistance to various antibiotics such as tetracycline, rifampin, and gentamicin.

Gene Information

Gene Name: iri
Allele: iri
Encodes: monooxygenase
Source Database: Reslit
Mechanism: antibiotic inactivation
Confers Resistance To: rifampicin
Organisms Tested In: • Rhodococcus
Geographic Location: Saudi Arabia|Arctium fruticosum rhizosphere
Validation Method: phageome analysis

2

Genomic characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic insights into Nocardia cyriacigeorgica.

PMID 40188140 · 2025

The study identified several antimicrobial resistance genes in Nocardia cyriacigeorgica, including VanSO and VanRO for vancomycin resistance, erm(O)-Irm, srmB, and ermH for macrolide resistance, bla1 and bcl for beta-lactam resistance, CTX-M and KPC for cephalosporin and carbapenem resistance, tetA(58) and tetB(58) for tetracycline resistance, folC and folP for sulfonamide resistance, rbpA and rpoB2 for rifamycin resistance, murA and AbaF for fosfomycin resistance, cmlR for chloramphenicol resistance, and VatF and VatE for streptogramin resistance.

Gene Information

Gene Name: iri
Allele: iri
Encodes: Monooxygenase that confers resistance to rifampin
Source Database: Reslit
Mechanism: Antibiotic inactivation
Confers Resistance To: rifamycins
Organisms Tested In: • Nocardia cyriacigeorgica
Geographic Location: China
Validation Method: BLASTP against CARD
Sequence Accession: SAMN46383565|GCA_027924465.1|GCA_010858005.1|SAMN46383563|GCA_015477225.1|GCA_015477975.1|GCA_000284035.1|GCA_015477645.1|GCA_029868645.1|GCA_027924275.1|GCA_010868115.1|GCA_010868145.1|GCA_010868155.1|GCA_029868385.1|GCA_005863245.1|GCA_005863295.1|GCA_015478165.1|GCA_015478435.1|GCA_015478155.1|SAMN46383564|GCA_015478075.1|GCA_010858045.1|GCA_015477995.1|SAMN46383566|GCA_015477865.1|GCA_029868465.1|GCA_900683635.1|GCA_015478375.1|GCA_015477145.1|GCA_015477345.1|GCA_015477725.1|GCA_015478465.1|SAMN46383567|GCA_015476895.1|GCA_015476905.1|GCA_015476925.1|GCA_015477945.1|GCA_015478055.1|GCA_029868825.1|GCA_002933455.1|GCA_029868925.1|GCA_029868665.1|GCA_029868765.1|GCA_029868805.1|GCA_029869825.1|GCA_029868685.1|GCA_029868705.1|GCA_002949635.1|GCA_029868265.1|GCA_029867605.1|GCA_029869675.1|GCA_029869725.1|GCA_029867685.1|GCA_029867665.1|GCA_029867565.1|GCA_000308555.1|GCA_005863225.1|GCA_029867425.1|GCA_029868785.1|GCA_029868005.1|PRJNA1214743

3

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.

PMID 8980786 · 1997

Gene Information

Gene Name: iri
Allele: iri
Encodes: rifampin monooxygenase Iri
Source Database: Reference Gene Catalog
Mechanism: antibiotic inactivation
Confers Resistance To: RIFAMPIN
Organisms Tested In: • Prescottella equi
Sequence Accession: U56415.1
Protein Accession: AAB41059.1
Notes: ARO:3002884

4

Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic.

PMID 8980786 · 1997

Gene Information

Gene Name: iri
Allele: iri
Encodes: rifampin monooxygenase Iri, rifampin monooxygenase
Source Database: Card Database
Mechanism: antibiotic inactivation
Confers Resistance To: RIFAMPIN
Organisms Tested In: • Prescottella equi
Sequence Accession: U56415.1
Protein Accession: AAB41059.1
Notes: ARO:3002884

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research