iscR

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transcriptional regulator

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to iscR

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Validation StatusCandidate

Overview

Mechanism: posttranscriptional regulation by OxyS and FnrS
Validation Method: beta-galactosidase activity, EMSA, northern blot, MIC assay
Drug Classes: aminoglycosides
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis in Escherichia coli.

PMID 39495911 · 2024

OxyS and FnrS regulate iscR expression in opposite ways, with OxyS enhancing resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis.

Gene Information

Gene Name: iscR
Allele: iscR
Encodes: transcriptional regulator
Source Database: Reslit
Mechanism: posttranscriptional regulation by OxyS and FnrS
Confers Resistance To: aminoglycosides
Organisms Tested In: • Escherichia coli
Validation Method: beta-galactosidase activity, EMSA, northern blot, MIC assay

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iscR

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iscR

Gene Information