ispa8

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transposase

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Validation StatusCandidate

Overview

Mechanism: insertion within oprD or its promoter region leading to inactivation of oprD
Validation Method: PCR and sequencing
Drug Classes: meropenem
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Emergence of carbapenem resistance due to the novel insertion sequence ISPa8 in Pseudomonas aeruginosa.

PMID 24614163 · 2014

The study identifies ISPa8 as a novel insertion sequence that contributes to carbapenem resistance in Pseudomonas aeruginosa by inserting into the oprD gene or its promoter region, causing inactivation of oprD.

Gene Information

Gene Name: ispa8
Allele: ISPa8
Encodes: transposase
Source Database: Reslit
Mechanism: insertion within oprD or its promoter region leading to inactivation of oprD
Confers Resistance To: meropenem
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: PCR and sequencing
Sequence Accession: KC710194|KC710195

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ispa8

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ispa8

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