kasB

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Beta-ketoacyl synthase

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Validation StatusCandidate

Overview

Mechanism: isoniazid resistance
Validation Method: chemical-genetic interaction analysis
Drug Classes: isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

CGA-LMM identifies expected interactions for anti-tubercular drugs with known mechanisms

PMID 34597304 · 2021

The study identifies genes involved in resistance to anti-tubercular drugs through chemical-genetic interaction analysis, highlighting gyrA, rpoB, thyA, ino1, and kasB as key players in resistance mechanisms for fluoroquinolones, rifampin, sulfamethoxazole, and isoniazid.

Gene Information

Gene Name: kasB
Allele: kasB
Encodes: Beta-ketoacyl synthase
Source Database: Reslit
Mechanism: isoniazid resistance
Confers Resistance To: isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: chemical-genetic interaction analysis

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kasB

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kasB

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