kdpB

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Potassium transport ATPase subunit

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to kdpB

AMR Rules

Browse AMR rules for kdpB

Validation StatusCandidate

Overview

Mechanism: potassium transport
Validation Method: proteomic analysis
Drug Classes: polymyxins, gentamicin, kanamycin
Organisms: Klebsiella pneumoniae, Staphylococcus aureus
Papers: 2
Databases: Reslit

Papers2

Antibiotic Resistance Diagnosis in ESKAPE Pathogens-A Review on Proteomic Perspective.

PMID 36980322 · 2023

This review discusses proteomic approaches for diagnosing antibiotic resistance in ESKAPE pathogens, highlighting the importance of proteomic techniques in understanding resistance mechanisms and improving diagnostic accuracy.

Gene Information

Gene Name: kdpB
Allele: kdpB
Encodes: Potassium transport ATPase subunit
Source Database: Reslit
Mechanism: potassium transport
Confers Resistance To: polymyxins
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: proteomic analysis

Adaptive laboratory-evolved MRSA with PPEF manifests cross-susceptibility to oxacillin and hypersensitivity to ciprofloxacin.

PMID 40662666 · 2025

The study identifies the downregulation of several AMR genes, including blaZ, mecR1, kdpB, ble, pbp, and ermA, in PPEF-evolved MRSA-PR strains, leading to increased susceptibility to antibiotics such as oxacillin, ciprofloxacin, gentamicin, and imipenem.