Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
SMR-type efflux pump
Overview
KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance.
The study identifies KpnEF, an SMR-type efflux pump, as a critical factor in broad-spectrum antimicrobial resistance in Klebsiella pneumoniae. Mutations in kpnEF lead to increased susceptibility to multiple antibiotics and disinfectants.
Antimicrobial Resistance in Multidrug-Resistant Pathogens: Focus on Polymyxin Resistance Mechanisms
This review discusses the antibacterial activity and mechanisms of resistance to polymyxins, focusing on their interaction with bacterial membranes and the genetic basis of resistance.
Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria.
The paper reviews intrinsic and acquired colistin resistance mechanisms in bacteria, highlighting the role of genes such as pmrA, pmrB, phoP, phoQ, mgrB, arnBCADTEF, and mcr genes in conferring resistance. It discusses the importance of these genes in the context of colistin resistance and their implications for clinical treatment.
ArcA modulates multidrug resistance and compound susceptibility in Klebsiella pneumoniae through ArcB-independent regulation of the SMR efflux pump kpnEF.
The study shows that ArcA modulates multidrug resistance and compound susceptibility in Klebsiella pneumoniae by regulating the SMR efflux pump kpnEF. Deletion of arcA leads to increased resistance to antibiotics, osmotic agents, disinfectants, and structurally related compounds, which is independent of arcB. The upregulation of kpnEF in the Δ arcA strain contributes to the reduced susceptibility.
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