lafB

glycosyltransferase

Overview

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W193R	C577T T577C	reduces the stability of EfLafB, loss of function	Enterococcus faecium, E. faecium	daptomycin	Reslit	Candidate

Papers2

Exploring Daptomycin Hypersensitivity in Enterococcus faecium: The Impact of LafB Mutation on Bacterial Virulence.

The W193R mutation in lafB leads to daptomycin hypersusceptibility and reduced virulence in E. faecium.

Protein Change: W193R
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin
Effect on Function: reduces the stability of EfLafB
Validation Method: growth curve analysis, biofilm formation assay, in vivo virulence assessment
Source Database: Reslit

Loss of LafB activity reverses daptomycin resistance in E. faecium.

Mutations in lafB lead to daptomycin hypersusceptibility.