lapB

lipid A biosynthesis protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to lapB

Browse AMR rules for lapB

Overview

Mechanism: lipopolysaccharide assembly protein LapB
Drug Classes: colistin
Organisms: Klebsiella pneumoniae, Klebsiella quasipneumoniae
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N212T	-	-	Klebsiella pneumoniae, Klebsiella quasipneumoniae	colistin	Reslit	Candidate
V43G	-	lipopolysaccharide assembly protein LapB	Klebsiella pneumoniae	colistin	Reference Gene Catalog	Candidate

Papers2

1

Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand.

PMID 39039157 · 2024

Mutation Information

Protein Change: N212T
Organisms: Klebsiella pneumoniae, Klebsiella quasipneumoniae
Confers Resistance To: colistin
Validation Method: genomic analysis
Source Database: Reslit

2

Genomic Characterization of Colistin Heteroresistance in Klebsiella pneumoniae during a Nosocomial Outbreak.

PMID 27600049 · 2016

lapB

Mutation Information

Protein Change: V43G
Organisms: Klebsiella pneumoniae
Confers Resistance To: colistin
Effect on Function: lipopolysaccharide assembly protein LapB
Source Database: Reference Gene Catalog