ldrD

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toxin

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to ldrD

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: growth inhibition via translation interference
Validation Method: controlled expression and susceptibility testing
Drug Classes: ampicillin, ofloxacin
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Toxin Induction or Inhibition of Transcription or Translation Posttreatment Increases Persistence to Fluoroquinolones.

PMID 34399616 · 2021

The study identifies LdrD and MazF as toxins that enhance persistence to fluoroquinolones by inducing growth inhibition and translation interference, demonstrating their role in increasing bacterial survival post-antibiotic treatment.

Gene Information

Gene Name: ldrD
Allele: ldrD
Encodes: toxin
Source Database: Reslit
Mechanism: growth inhibition via translation interference
Confers Resistance To: ampicillinofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: controlled expression and susceptibility testing

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ldrD

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ldrD

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