lepA

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translation-associated elongation factor

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Protein entries specific to lepA

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Validation StatusCandidate

Overview

Mechanism: disruption leads to increased rifampicin tolerance
Validation Method: transposon insertion mutagenesis and deep sequencing (Tnseq), complementation studies
Drug Classes: rifampicin
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis
Papers: 1
Databases: Reslit

Papers1

Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance.

PMID 32439911 · 2020

Mutations in the mycobacterial gene lepA lead to rifampicin-specific phenotypic resistance by increasing rifampicin tolerance through altered transcriptional responses.

Gene Information

Gene Name: lepA
Allele: lepA
Encodes: translation-associated elongation factor
Source Database: Reslit
Mechanism: disruption leads to increased rifampicin tolerance
Confers Resistance To: rifampicin
Organisms Tested In: • Mycobacterium smegmatis
• Mycobacterium tuberculosis
Validation Method: transposon insertion mutagenesis and deep sequencing (Tnseq), complementation studies

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lepA

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lepA

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