Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
leucine-tRNA synthetase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R422C | - | - | Staphylococcus aureus | ciprofloxacin | Reslit | Candidate |
tRNA Synthetase Mutants of Escherichia coli K-12 Are Resistant to the Gyrase Inhibitor Novobiocin.
Mutations in tRNA synthetase genes (alaS, argS, ileS, leuS) and rpoN confer resistance to the gyrase inhibitor novobiocin in Escherichia coli K-12 through the RelA-mediated stringent response.
A Study of Antibiotic Tolerance to Levofloxacin and Rifampin in Staphylococcus aureus Isolates Causing Prosthetic Joint Infections: Clinical Relevance and Treatment Challenges.
The study identified sspA and leuS as genes associated with increased levofloxacin tolerance in biofilm-forming S. aureus isolates, and prs and pgm as genes linked to rifampin tolerance in non-biofilm isolates.
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