lexA

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LexA repressor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to lexA

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: mutation assay and MIC determination
Drug Classes: ciprofloxacin, ciprofloxacin|levofloxacin
Organisms: Escherichia coli, Pseudomonas aeruginosa
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S119A	-	-	Escherichia coli	ciprofloxacin	Reslit	Candidate
S125A	C374A	-	Pseudomonas aeruginosa, Escherichia coli	ciprofloxacin\|levofloxacin	Reslit	Candidate

Papers3

Inhibition of mutation and combating the evolution of antibiotic resistance.

PMID 15869329 · 2005

The study shows that preventing LexA cleavage inhibits the evolution of resistance to ciprofloxacin and rifampicin in E. coli by blocking the SOS response and subsequent mutagenesis.

Gene Information

Gene Name: lexA
Allele: lexA
Encodes: LexA repressor
Source Database: Reslit
Confers Resistance To: ciprofloxacin
Organisms Tested In: • Escherichia coli
Validation Method: mutation assay and MIC determination
Sequence Accession: NT01EC2662|NT01EC4829

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lexA

Mutations

Gene Information

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lexA

Mutations

Gene Information