Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major facilitator superfamily (MFS) antibiotic efflux pump
Overview
LfrR is a repressor that regulates expression of the efflux pump LfrA in Mycobacterium smegmatis.
The study identifies LfrA as an efflux pump that confers resistance to fluoroquinolones, cationic dyes, and anthracyclines in Mycobacterium smegmatis. LfrR acts as a repressor of LfrA expression, and its deletion leads to increased resistance to these compounds.
Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance.
The study identifies lfrA as a primary efflux pump involved in ethidium bromide extrusion in Mycobacterium smegmatis, and mspA as a major porin affecting ethidium bromide influx. Disruption of lfrA increases susceptibility to several antibiotics, while deletion of mspA reduces ethidium bromide accumulation and enhances resistance.
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.
The paper discusses the role of transport mechanisms, particularly efflux pumps, in Mycobacterium tuberculosis drug resistance and tolerance, highlighting the importance of efflux pump activity in reducing drug susceptibility.
Efflux Pump Inhibition and Resistance Modulation in Mycobacterium smegmatis by Peucedanum ostruthium and Its Coumarins.
The study identifies the LfrA efflux pump as a key target for resistance modulation in Mycobacterium smegmatis, showing that imperatorin (4) significantly enhances the susceptibility of the bacterium to ethidium bromide by inhibiting this efflux pump.
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