Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
putative transmembrane protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D191N | - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate |
| R177C | - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate |
| T194I | - | single resistance variant, three-component signaling pathway regulator LiaF | Enterococcus faecalis | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| I144T | - | single resistance variant, three-component signaling pathway regulator LiaF | Enterococcus faecium | daptomycin | Card DatabaseReference Gene Catalog | Candidate |
| L39F | - | single resistance variant | Enterococcus faecium | daptomycin | Card Database | Candidate |
| I171del | - | three-component signaling pathway regulator LiaF | Enterococcus faecalis | daptomycin | Reference Gene Catalog | Candidate |
| G135A | - | three-component signaling pathway regulator LiaF | Enterococcus faecium | daptomycin | Reference Gene Catalog | Candidate |
| E239G | - | three-component signaling pathway regulator LiaF | Enterococcus faecium | daptomycin | Reference Gene Catalog | Candidate |
| - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate | |
| - | - | Enterococcus faecalis | daptomycin | Reslit | Candidate |
Genetic basis for in vivo daptomycin resistance in enterococci.
Mutations in the genes encoding LiaF and a GdpD-family protein were necessary and sufficient for the development of resistance to daptomycin in Enterococcus faecalis. Additionally, an Arg218 Gln substitution in the Cls enzyme was found in daptomycin-resistant E. faecium isolates.
The rise of the Enterococcus: beyond vancomycin resistance.
The paper discusses the mechanisms of antibiotic resistance in Enterococcus, particularly focusing on ampicillin resistance mediated by the pbp5R gene in hospital-associated E. faecium isolates.
Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.
The study identified mutations in the liaF, liaR, yvlB, and cls genes that contribute to daptomycin resistance in Enterococcus faecalis through a defined evolutionary pathway involving the LiaFSR signaling pathway and changes in membrane composition.
Complete Genomic Analysis of VRE From a Cattle Feedlot: Focus on 2 Antibiotic Resistance.
The study identified multiple antibiotic resistance genes in vancomycin-resistant enterococci (VRE) isolates from a cattle feedlot, including vanC1, vanC2/C3, vanXY-C, VanR, macA, macB, rlmA (II), erm(A), aac(6')-la, blaEC, tet(A), tet(L), S10p, gyrA, gyrB, msbA, S12p, rpoB, mdfA/cmr, liaF, liaR, liaS, bcrC, mprF, pgsA, ef-G, ef-TU, ddl, alr, kasA, isotRNA, inhA, fabl, murA, folA, and Dfr, which confer resistance to various antibiotics such as vancomycin, macrolides, aminoglycosides, β-lactams, tetracyclines, quinolones, and others.
Arginine impacts aggregation, biofilm formation, and antibiotic susceptibility in Enterococcus faecalis.
Arginine metabolism in Enterococcus faecalis leads to increased aggregation, decreased biofilm formation, and altered antibiotic susceptibility, particularly to ampicillin and ceftriaxone.
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