Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
LiaFSR signaling pathway regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T120A | - | - | Enterococcus faecalis, Enterococcus faecium | daptomycin | Reslit | Candidate |
| W73C | constitutive activation, mutated, single resistance variant, response regulator transcription factor LiaR | Enterococcus faecium | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| E75K | - | response regulator transcription factor LiaR | Enterococcus faecalis, Enterococcus faecium | daptomycin | ReslitReference Gene Catalog | Candidate |
| D191N | - | enhances DNA binding affinity and oligomerization, single resistance variant, response regulator transcription factor LiaR | Enterococcus faecalis | daptomycin | ReslitCard DatabaseReference Gene Catalog | Candidate |
| S19F | - | response regulator transcription factor LiaR | Enterococcus faecium | daptomycin | ReslitReference Gene Catalog | Candidate |
| - | - | Enterococcus faecium | daptomycin | Reslit | Candidate | |
| - | - | - | daptomycin | Reslit | Candidate |
Adaptation of Enterococcus faecalis to daptomycin reveals an ordered progression to resistance.
The study identified mutations in the liaF, liaR, yvlB, and cls genes that contribute to daptomycin resistance in Enterococcus faecalis through a defined evolutionary pathway involving the LiaFSR signaling pathway and changes in membrane composition.
Emergence of vancomycin-resistant Enterococcus faecium vanA ST612 with reduced daptomycin susceptibility, Switzerland, 2018 to 2024.
The study identifies mutations in liaR (W73C) and liaS (T120A) associated with reduced daptomycin susceptibility in vancomycin-resistant Enterococcus faecium vanA ST612. It also characterizes resistance genes including vanA, aac(6')-I, msr(C), and ant(6)-Ia.
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