lptA

lysophosphatidic acid acyltransferase

Overview

Mechanism: partially recovered the ability to copurify with LptC
Drug Classes: amikacin, bacitracin
Organisms: Pseudomonas aeruginosa, Escherichia coli
Papers: 2
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T55A	-	-	Pseudomonas aeruginosa	amikacin	Reslit	Candidate
R62S	-	-	Pseudomonas aeruginosa	amikacin	Reslit	Candidate
M112I	-	partially recovered the ability to copurify with LptC	Escherichia coli	bacitracin	Reslit	Candidate

Papers2

The predictive potential of different molecular markers linked to amikacin susceptibility phenotypes in Pseudomonas aeruginosa.

PMID 35468158 · 2022

Mutation Information

lptA: p.T55A lptA: p.R62S

Protein Change: T55A, R62S
Organisms: Pseudomonas aeruginosa
Confers Resistance To: amikacin
Validation Method: statistical and functional analysis
Source Database: Reslit

Mutation and Suppressor Analysis of the Essential Lipopolysaccharide Transport Protein LptA Reveals Strategies To Overcome Severe Outer Membrane Permeability Defects in Escherichia coli.

PMID 29109183 · 2018

The lptA42 allele encodes an additional amino acid change (M112I) in LptA41, which partially recovered the ability to copurify with LptC.

Mutation Information

lptA: p.M112I

Protein Change: M112I
Organisms: Escherichia coli
Confers Resistance To: bacitracin
Effect on Function: partially recovered the ability to copurify with LptC
Validation Method: cloning in E. coli + disk diffusion
Source Database: Reslit

Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

T55A

Pseudomonas aeruginosa

amikacin

Reslit

Candidate

R62S

Pseudomonas aeruginosa

amikacin

Reslit

Candidate

M112I

partially recovered the ability to copurify with LptC

Escherichia coli

bacitracin

Reslit

Candidate

lptA

Mutations

Mutation Information

Mutation Information

Browse AMR Genes

lptA

Mutations

Mutation Information

Mutation Information