lptD

outer membrane protein

Overview

Drug Classes: colistin, vancomycin
Organisms: Pseudomonas aeruginosa, Klebsiella pneumoniae
Papers: 3
Mutations: 5

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y803X	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
G580S	-	-	-	colistin	Reslit	Candidate
G348D	-	-	-	vancomycin	Reslit	Candidate
S350N	-	-	-	vancomycin	Reslit	Candidate
-	A316G	-	Klebsiella pneumoniae	colistin	Reslit	Candidate

Papers3

Rapid and Consistent Evolution of Colistin Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa during Morbidostat Culture.

PMID 28630206 · 2017

Observed in PA77 cultures

Mutation Information

lptD: p.Y803X

Protein Change: Y803X
Organisms: Pseudomonas aeruginosa
Confers Resistance To: colistin
Validation Method: whole-genome deep sequencing
Source Database: Reslit

Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.

PMID 32324807 · 2020

LptD G580S mutation increases resistance to vancomycin, antimicrobial peptides, and n-hexane while decreasing sensitivity to cholic acid.

Mutation Information

lptD: p.G580S lptD: p.G348D lptD: p.S350N

Protein Change: G580S, G348D, S350N
Confers Resistance To: colistinvancomycin
Validation Method: transduction and sequencing
Source Database: Reslit

Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics.

PMID 33139278 · 2020