Browse AMR Genes

Explore antimicrobial resistance genes from the literature

lptE

outer membrane protein involved in lipopolysaccharide transport

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to lptE

Browse AMR rules for lptE

Overview

Drug Classes: colistin, vancomycin
Papers: 1
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T95I	-	-	-	colistin	Reslit	Candidate
E139K	-	-	-	vancomycin	Reslit	Candidate

Papers1

1

Non-pathogenic Escherichia coli acquires virulence by mutating a growth-essential LPS transporter.

PMID 32324807 · 2020

LptE T95I mutation increases resistance to vancomycin, antimicrobial peptides, and n-hexane while decreasing sensitivity to cholic acid.

Mutation Information

lptE: p.T95I lptE: p.E139K

Protein Change: T95I, E139K
Confers Resistance To: colistinvancomycin
Validation Method: transduction and sequencing
Source Database: Reslit