lpxB

lipid A biosynthesis enzyme

Overview

Drug Classes: polymyxin b, colistin
Organisms: Acinetobacter baumannii
Papers: 2
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E3K	-	-	-	polymyxin b	Reslit	Candidate
C120R	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate
N287O	-	-	Acinetobacter baumannii	colistin	Reslit	Candidate

Papers2

Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.

PMID 34516251 · 2021

associated with synergy

Mutation Information

lpxB: p.E3K

Protein Change: E3K
Confers Resistance To: polymyxin b
Validation Method: association with synergy in combination with polymyxin B
Source Database: Reslit

Genotypic and Phenotypic Characterization of Novel Sequence Types of Carbapenem-Resistant Acinetobacter baumannii, With Heterogeneous Resistance Determinants and Targeted Variations in Efflux Operons.

PMID 35002996 · 2021

Mutations in lpxB gene associated with colistin resistance

Mutation Information

lpxB: p.C120R lpxB: p.N287O

Protein Change: C120R, N287O
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Validation Method: genomic analysis
Source Database: Reslit

lpxB

Mutations

Mutation Information

Mutation Information

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lpxB

Mutations

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