lso

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sterol C-5-desaturase

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UniProt

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Validation StatusCandidate

Overview

Validation Method: genetic knockout and sterol composition analysis
Drug Classes: amphotericin b
Organisms: Leishmania major
Papers: 1
Databases: Reslit

Papers1

Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major.

PMID 32611698 · 2020

Deletion of LSO in Leishmania major conferred resistance to Amphotericin B but caused hypersensitivity to acidic stress and defects in intracellular pH regulation.

Gene Information

Gene Name: lso
Allele: LSO
Encodes: sterol C-5-desaturase
Source Database: Reslit
Confers Resistance To: amphotericin b
Organisms Tested In: • Leishmania major
Validation Method: genetic knockout and sterol composition analysis

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lso

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lso

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