lysX

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lysyl-diacylglycerol synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to lysX

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Validation StatusCandidate

Overview

Validation Method: genetic disruption and MIC testing
Drug Classes: aminoglycosides
Organisms: Corynebacterium pseudotuberculosis, Mycobacterium abscessus, Mycobacterium parafinicum
Papers: 1
Databases: Reslit

Papers1

The MprF homolog LysX synthesizes lysyl-diacylglycerol contributing to antibiotic resistance and virulence.

PMID 37768052 · 2023

LysX from Corynebacterium pseudotuberculosis and mycobacterial species synthesizes lysyl-diacylglycerol (Lys-DAG), which contributes to resistance against cationic antimicrobial peptides and aminoglycosides. LysX also plays a role in virulence in a Galleria mellonella infection model.

Gene Information

Gene Name: lysX
Allele: lysX
Encodes: lysyl-diacylglycerol synthase
Source Database: Reslit
Confers Resistance To: aminoglycosides
Organisms Tested In: • Corynebacterium pseudotuberculosis
• Mycobacterium abscessus
• Mycobacterium parafinicum
Validation Method: genetic disruption and MIC testing

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lysX

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lysX

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