macA

periplasmic membrane fusion protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to macA

Browse AMR rules for macA

Overview

Mechanism: disrupts the proper assembly of the MacA-MacB complex
Drug Classes: erythromycin|oleandomycin, macrolides
Organisms: Escherichia coli
Papers: 1
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G353A	-	disrupts the proper assembly of the MacA-MacB complex	Escherichia coli	erythromycin\|oleandomycin	Reslit	Candidate
G357A	-	modest effect on the MP domain of MacA	Escherichia coli	erythromycin\|oleandomycin	Reslit	Candidate
-	G353A	reduces resistance to macrolides in vivo	Escherichia coli	macrolides	Reslit	Candidate

Papers1

1

The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter.

PMID 21696464 · 2011

The G353A mutation in MacA reduces resistance to macrolides in vivo.

Mutation Information

macA: p.G353A macA: p.G357A

Protein Change: G353A, G357A
Organisms: Escherichia coli
Confers Resistance To: erythromycin|oleandomycinmacrolides
Effect on Function: disrupts the proper assembly of the MacA-MacB complex; modest effect on the MP domain of MacA; reduces resistance to macrolides in vivo
Validation Method: MIC testing and proteolysis experiments; In vivo and in vitro biochemical analyses
Source Database: Reslit