Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
global regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G103S | - | single resistance variant | Escherichia coli, Escherichia spp. | nalidixic acid|ciprofloxacin|ampicillin|kanamycin|streptomycin|rifampicin|tetracycline|phenicols|trimethoprim|sulfamethoxazoletigecyclineciprofloxacin+2 more | ReslitCard Database | Candidate |
| T39I | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| M74I | - | - | E. coli | tetracycline | Reslit | Candidate |
| C108Y | - | loss-of-function | Escherichia coli | ampicillin|tetracycline | Reslit | Candidate |
| L46P | - | loss-of-function | Escherichia coli | ampicillin|tetracycline | Reslit | Candidate |
| R296H | - | - | Escherichia coli | phenicols | Reslit | Candidate |
| G22D | - | - | Escherichia coli | ampicillin | Reslit | Candidate |
| G28R | - | - | Escherichia coli | fluoroquinolones | Reslit | Candidate |
| M1V | - | - | - | carbapenemscarbapenems|colistin | Reslit | Candidate |
| V66A | - | - | Escherichia coli | ceftriaxone | Reslit | Candidate |
| R62C | - | - | Escherichia coli | gatifloxacin | Reslit | Candidate |
| S83L | - | Escherichia coli | ciprofloxacin | Reslit | Candidate | |
| L71P | - | - | - | tigecycline | Reslit | Candidate |
| K44Y | - | - | - | tigecycline | Reslit | Candidate |
| A53E | - | - | - | tigecycline | Reslit | Candidate |
| M1G | - | - | - | tigecycline | Reslit | Candidate |
| Y137H | - | single resistance variant | Escherichia spp., Escherichia coli | tigecyclineciprofloxacinmultiple antibiotics | ReslitCard Database | Candidate |
| V84E | - | - | E. coli, Escherichia coli | phenicols|ciprofloxacinciprofloxacin | Reslit | Candidate |
| L109F | - | - | E. coli | phenicols | Reslit | Candidate |
| V11I | - | mutations that relieve transcriptional repression by MarR consequently upregulate the expression of the efflux pump and increase antibiotic resistance | Shewanella oneidensis | ciprofloxacin | Reslit | Candidate |
| S3N | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | fluoroquinolonesphenicols|rifampicinmultiple antibiotics+1 more | ReslitCard DatabaseReference Gene Catalog | Candidate |
| L78R | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| E136D | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| 22fs | - | loss of repressor activity | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| G81C | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| G81D | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| D87G | - | - | Escherichia coli | ciprofloxacin|levofloxacin | Reslit | Candidate |
| R27P | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L33R | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| Q42E | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| G69E | - | Escherichia coli | levofloxacinphenicolsdelafloxacin|ciprofloxacin | Reslit | Candidate | |
| T102S | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L123S | - | - | Escherichia coli | levofloxacin | Reslit | Candidate |
| L115P | - | - | - | ciprofloxacin | Reslit | Candidate |
| R73S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | phenicolsmultiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | ReslitCard DatabaseReference Gene Catalog | Candidate |
| G104C | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| D67Y | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| W63R | - | - | E. coli | ciprofloxacin | Reslit | Candidate |
| R94H | single resistance variant, transcriptional regulator MarR | E. coli, Escherichia coli | ciprofloxacinmultiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline+1 more | ReslitCard DatabaseReference Gene Catalog | Candidate | |
| V41M | - | - | Escherichia coli | benzalkonium chloride|phenicols|triclosan | Reslit | Candidate |
| R152C | - | - | Escherichia coli | benzalkonium chloride|phenicols|triclosan | Reslit | Candidate |
| L75R | - | - | Escherichia coli | ciprofloxacin | Reslit | Candidate |
| D67N | - | - | Escherichia coli | fluoroquinolones | Reslit | Candidate |
| V66F | - | - | Escherichia coli | ampicillin | Reslit | Candidate |
| R94S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| V96E | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| I49S | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| R77C | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| V45E | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| E31Ter | - | nonsense mutation, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| R73C | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| A70T | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| L78M | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| R77L | - | single resistance variant, transcriptional regulator MarR | Escherichia coli | multiple antibioticsampicillin|phenicols|quinolones|rifampicin|tetracycline | Card DatabaseReference Gene Catalog | Candidate |
| R58L | - | single resistance variant | Escherichia coli | multiple antibiotics | Card Database | Candidate |
| T72P | - | - | delafloxacin | Reslit | Candidate | |
| - | - | Escherichia coli | norfloxacin | Reslit | Candidate | |
| - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate | |
| G69R | - | - | delafloxacin | Reslit | Candidate | |
| R86S | - | - | ciprofloxacin | Reslit | Candidate | |
| G106D | - | Escherichia coli | tetracycline|phenicols | Reslit | Candidate | |
| M74T | - | E. coli | tetracycline | Reslit | Candidate | |
| L87W | - | - | ciprofloxacin | Reslit | Candidate | |
| - | - | Escherichia coli | phenicols | Reslit | Candidate |
Intrinsic mechanism decreases susceptibility of Escherichia coli O157:H7 to multiple antibiotics.
Chloramphenicol-resistant mutants of Escherichia coli O157:H7 showed increased resistance to tetracycline, nalidixic acid, and ciprofloxacin. Mutation in the mar operon was linked to decreased susceptibility.
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