mcbR

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transcriptional regulator McbR

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mcbR

AMR Rules

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Validation StatusCandidate

Overview

Mechanism: regulation of efflux pump genes
Validation Method: RT-qPCR and CFU assays
Drug Classes: cefotaxime, cephalexin, gentamicin, clindamycin, lincomycin, doxycycline, tetracycline, kanamycin, norfloxacin, ofloxacin, erythromycin, rifampicin
Organisms: Avian pathogenic Escherichia coli X40
Papers: 1
Databases: Reslit

Papers1

Role of McbR in the regulation of antibiotic susceptibility in avian pathogenic Escherichia coli.

PMID 33248554 · 2020

The study shows that McbR regulates the transcription of efflux pump genes (acrA, acrB, acrD, acrR, emrD, mdtD) in APECX40, thereby affecting antibiotic susceptibility. Deletion of mcbR increases susceptibility to 12 antibiotics, while overexpression decreases susceptibility.

Gene Information

Gene Name: mcbR
Allele: mcbR
Encodes: transcriptional regulator McbR
Source Database: Reslit
Mechanism: regulation of efflux pump genes
Confers Resistance To: cefotaximecephalexingentamicinclindamycinlincomycindoxycyclinetetracyclinekanamycinnorfloxacinofloxacinerythromycinrifampicin
Organisms Tested In: • Avian pathogenic Escherichia coli X40
Validation Method: RT-qPCR and CFU assays

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mcbR

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mcbR

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