Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
phosphoethanolamine--lipid A transferase MCR-7.1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MCR-7.1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 11 | COLISTIN, colistin +1 | Klebsiella pneumoniae +3 | China|Belgium|Italy|Germany|Spain|Brazil|Denmark|United Kingdom|Canada|Argentina|Japan|Australia|France|South Korea|United States, Brazil, USA|United States|China|Sri Lanka|Germany|Greece, China|United States|United Kingdom|Europe, Stellenbosch, South Africa, global|China|Thailand|USA|Turkey|Spain|Nigeria|Korea|Japan|Italy|France|England|Czech Republic|Cambodia|Brazil|Belgium|Bangladesh|Portugal|Canada|Switzerland|Germany, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Malawi|Uganda|Zanzibar|UK|Vietnam | 2018, 2020, 2022, 2024, 2025 | MG267386.1 | AUR80098.1 |
| mcr-7.1 | ResFinder Database | 1 | COLISTIN | Klebsiella pneumoniae | - | 2018 | MG267386 | - |
| mcr-7 | Reslit | 12 | colistin, polymyxins | Klebsiella pneumoniae +14 | China|Belgium|Italy|Germany|Spain|Brazil|Denmark|United Kingdom|Canada|Argentina|Japan|Australia|France|South Korea|United States, China|Europe|North America|Asia|United Kingdom|Germany|Belgium|France|Switzerland, United States, Egypt, Thailand, global|China|Thailand|USA|Turkey|Spain|Nigeria|Korea|Japan|Italy|France|England|Czech Republic|Cambodia|Brazil|Belgium|Bangladesh|Portugal|Canada|Switzerland|Germany, Brazil, Cambodia, China|Belgium|Switzerland|India|Philippines|Japan|Thailand, Europe|Asia|North America|South America | 2018, 2020, 2021, 2022, 2023, 2025 | KP347127.1|AKF16168.1|WP_049589868.1|KX236309.1|ANR95875.1|WP_065274078.1|KU934208.1|ANJ15621.1|WP_077064885.1|KY041856.1|APM87143.1|WP_076611062.1|KY283125.1|APM84488.1|WP_076611061.1|KY352406.1|AQK48217.1|WP_077248208.1|KY488488.1|AQQ11622.1|WP_085562392.1|KY683842.1|AQY61516.1|WP_085562407.1|KY964067.1|ASK38392.2|WP_099982800.1|MF176238.1|ASK49940.1|WP_096807442.1|KY853650.1|ATM29809.1|WP_099982815.1|LC337668.1|BBB21811.1|WP_104009850.1|MG384739.1|AVM85874.1|WP_109545056.1|LT598652.1|SBV31106.1|WP_065419574.1|MF176239.1|ASK49941.1|WP_078254299.1|KY924928.1|ASF81896.1|WP_039026394.1|MF495680.1|ASU10319.1|WP_099982814.1|FLXA01000011.1|SBZ31568.1|WP_065804663.1|MF489760.1|ASU04896.1|WP_089613755.1|MF598076.1|AST36140.1|WP_042649074.1|MF598077.1|AST36141.1|WP_099156047.1|MF598078.1|AST36143.1|WP_099156048.1|MF598080.1|AST36144.1|WP_099156049.1|MG214531.1|ATQ63376.1|WP_099982820.1|MG489958.1|AUN87920.1|WP_102607465.1|MG564491.1|AVZ47168.1|WP_109545070.1|MF543359.1|ASR73329.1|WP_099156046.1|MF543359.1|ASR73329.1|WP_099156046.1|MF598076.1|AST36140.1|WP_042649074.1|MG822663.1|AVK94777|WP_109545058.1|MG026621.1|AUI38915.1|WP_011638903.1|MG822665.1|AVK94779.1|WP_109545055.1|MG822664.1|AVK94778.1|WP_109545054.1|KY807921.1|ASK40551.1|WP_053821788.1|MG384740.1|AVM85875.1|WP_109545057.1|MF176240.1|ASK49942.1|WP_099982813.1|MG267386.1|AUR80098.1|WP_104009851.1 | - |
| MCR7.1 | Reslit | 1 | polymyxins | - | Amazon region | 2022 | - | - |
| mcr-7-like | Reslit | 1 | colistin | Aeromonas jandaei | Malawi|Uganda|Zanzibar|UK|Vietnam | 2025 | AP025277|AP026732|JN205800 | - |
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae.
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae.
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae.
Novel plasmid-mediated colistin resistance gene mcr-7.1 in Klebsiella pneumoniae.
Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes.
The paper proposes a standardized nomenclature for mobile colistin resistance (mcr) genes, focusing on the assignment of allele numbers to ensure clarity and consistency in identifying and characterizing these genes across different bacterial species and geographic locations.
Proposal for assignment of allele numbers for mobile colistin resistance (mcr) genes.
The paper proposes a standardized nomenclature for mobile colistin resistance (mcr) genes, focusing on the assignment of allele numbers to ensure clarity and consistency in identifying and characterizing these genes across different bacterial species and geographic locations.
Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)
The paper reviews the mechanisms of colistin resistance in multidrug-resistant Gram-negative bacteria, highlighting chromosomal mutations in genes such as pmrA, pmrB, phoP, phoQ, and mgrB that alter LPS modifications and contribute to resistance.
Co-occurrence of mcr-1, mcr-3, mcr-7 and clinically relevant antimicrobial resistance genes in environmental and fecal samples.
The study identified the co-occurrence of mcr-1, mcr-3, mcr-7.1, and various clinically relevant antimicrobial resistance genes in environmental and fecal samples from a Brazilian zoo, highlighting the potential reservoir of these genes in zoological environments.
Identification of Antimicrobial Resistance Determinants in Aeromonas veronii Strain MS-17-88 Recovered From Channel Catfish (Ictalurus punctatus).
The study identified multiple antimicrobial resistance genes in Aeromonas veronii strain MS-17-88, including beta-lactamase genes (imiS, ampS), phenicol resistance genes (floR, catB2, catB7, vat(F)), colistin resistance genes (mcr-3, mcr-7.1), tetracycline resistance genes (tet(34), tet(35), tet(E)), and a trimethoprim resistance gene (dfrA3).
Prevalence and Genetic Analysis of Chromosomal mcr-3/7 in Aeromonas From U.S. Animal-Derived Samples.
The study identified chromosomal mcr-3 and mcr-7 genes in Aeromonas strains from U.S. animal-derived samples, highlighting their role in colistin resistance.
Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria.
The paper reviews intrinsic and acquired colistin resistance mechanisms in bacteria, highlighting the role of genes such as pmrA, pmrB, phoP, phoQ, mgrB, arnBCADTEF, and mcr genes in conferring resistance. It discusses the importance of these genes in the context of colistin resistance and their implications for clinical treatment.
Virulence Determinants and Plasmid-Mediated Colistin Resistance mcr Genes in Gram-Negative Bacteria Isolated From Bovine Milk.
The study identified plasmid-mediated colistin resistance genes mcr-1, mcr-2, mcr-3, mcr-4, and mcr-7 in Gram-negative bacteria isolated from bovine milk, highlighting the spread of these genes among various bacterial species.
Klebsiella pneumoniae Complex Harboring mcr-1, mcr-7, and mcr-8 Isolates from Slaughtered Pigs in Thailand.
The study identified mcr-7 and mcr-8 genes in Klebsiella pneumoniae complex isolates from slaughtered pigs in Thailand, highlighting their role in colistin resistance.
Resistome Analysis of Global Livestock and Soil Microbiomes.
The study identified numerous antimicrobial resistance genes (ARGs) in livestock and soil microbiomes, including tetracycline resistance genes (tet(W)_1, tet(Q)_1, tet(O)_1, tet(44)_1), macrolide resistance gene (ole(B)_1), colistin resistance genes (mcr-1.11, mcr-5.1, mcr-7.1), and vancomycin resistance genes (vanG, vanA-B, vanH-B, vanXY-G).
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.
Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update.
The paper reviews the global epidemiology, genetic environment, risk factors, and therapeutic prospects of mcr genes, highlighting their dissemination in Enterobacteriaceae species and the role of mobile genetic elements in their spread. It identifies multiple mcr genes, including mcr-1 to mcr-10, and discusses their mechanisms of colistin resistance.
Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update.
The paper reviews the global epidemiology, genetic environment, risk factors, and therapeutic prospects of mcr genes, highlighting their dissemination in Enterobacteriaceae species and the role of mobile genetic elements in their spread. It identifies multiple mcr genes, including mcr-1 to mcr-10, and discusses their mechanisms of colistin resistance.
Impacts of soybean agriculture on the resistome of the Amazonian soil.
The study identified numerous antibiotic and biocide resistance genes in Amazonian soils, with a focus on the impact of soybean agriculture. Key findings include the prevalence of resistance to tetracycline, cephalosporin, penam, fluoroquinolone, chloramphenicol, carbapenem, macrolide, and aminoglycoside antibiotics, along with resistance to heavy metals and biocides.
Genomic Characterization of Aeromonas veronii Provides Insights into Taxonomic Assignment and Reveals Widespread Virulence and Resistance Genes throughout the World.
The study identifies mcr-7 and cphA as resistance genes in Aeromonas veronii, highlighting the presence of colistin and beta-lactam resistance mechanisms.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
The study identified various AMR genes and mutations in bacterial isolates from Cambodia, including extended-spectrum beta-lactamase genes (blaCTX-M-15, blaCTX-M-27, blaCTX-M-55), carbapenemase genes (blaOXA-23, blaNDM-1, blaOXA-58, blaOXA-66), and colistin resistance genes (mcr-1, mcr-3, mcr-7, mcr-9). Additionally, mutations in gyrA (S83F) and parC (S84L) were found to confer fluoroquinolone resistance in Salmonella enterica serovars Paratyphi A and Typhi.
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.
The study identifies that ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro, with resistance mutations already present in natural populations and mobile resistance genes prevalent in clinical isolates, soil, and human gut microbiomes.
Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents.
The study identifies several carbapenemase and colistin resistance genes in freshwater snail faecal metagenomes, highlighting their potential role as environmental reservoirs of antimicrobial resistance.
Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents.
The study identifies several carbapenemase and colistin resistance genes in freshwater snail faecal metagenomes, highlighting their potential role as environmental reservoirs of antimicrobial resistance.
Understanding Recent Developments in Colistin Resistance: Mechanisms, Clinical Implications, and Future Perspectives.
The paper discusses the emergence and spread of plasmid-mediated MCR genes (MCR-1 to MCR-10) that confer colistin resistance in Gram-negative bacteria, emphasizing their role in reducing the efficacy of colistin as a last-resort antibiotic.
Aeromonas Infections in Humans-Antibiotic Resistance and Treatment Options.
The paper discusses the emergence of multidrug-resistant Aeromonas strains, highlighting the presence of various beta-lactamases (blaCphA, blaKPC, blaNDM, blaVIM), polymyxin resistance genes (mcr-3, mcr-7), and fluoroquinolone resistance (qnrA).
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