mdr2

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ABC transporter

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UniProt

Protein entries specific to mdr2

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Validation StatusCandidate

Overview

Mechanism: mutation in gene leads to resistance
Validation Method: whole genome re-sequencing and di-deoxy sequencing
Drug Classes: sulfadoxine
Papers: 1
Databases: Reslit

Papers1

Whole genome re-sequencing identifies a mutation in an ABC transporter (mdr2) in a Plasmodium chabaudi clone with altered susceptibility to antifolate drugs.

PMID 20858498 · 2011

The study identifies a mutation in the mdr2 gene, which is associated with sulphadoxine resistance in a Plasmodium chabaudi clone. The mutation K392Q in mdr2 is linked to altered susceptibility to antifolate drugs.

Gene Information

Gene Name: mdr2
Allele: mdr2
Encodes: ABC transporter
Source Database: Reslit
Mechanism: mutation in gene leads to resistance
Confers Resistance To: sulfadoxine
Validation Method: whole genome re-sequencing and di-deoxy sequencing
Sequence Accession: PMC3034870

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mdr2

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mdr2

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