Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump system
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MdsAB | Reslit | 1 | fluoroquinolones, chloramphenicol florfenicol +1 | Salmonella enterica serovar Typhimurium | - | 2022 | - | - |
| mdsAB | Reslit | 1 | cephalosporins, aztreonam +10 | Salmonella Gallinarum | Colombia | 2023 | PRJNA483415 | - |
Mathematical Modelling Highlights the Potential for Genetic Manipulation as an Adjuvant to Counter Efflux-Mediated MDR in Salmonella.
The study highlights the role of RND efflux pump systems in mediating multidrug resistance (MDR) in Salmonella, particularly focusing on AcrAB, AcrEF, MdsAB, and MdtAB. Experimental data shows that overexpression of these efflux pumps leads to resistance against fluoroquinolones, chloramphenicol-florfenicol, and tetracyclines.
Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
The study identified 26 chromosomal resistance genes in Salmonella Gallinarum strains, primarily encoding efflux pumps, and point mutations in gyrase genes (gyrA and gyrB) associated with quinolone resistance. The gyrB mutation S464T was frequently found in Colombian strains.
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