Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump component
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T224K | - | - | - | fluoroquinolonesfluoroquinolones|beta lactams | Reslit | Candidate |
Molecular typing and virulence analysis of multidrug resistant Klebsiella pneumoniae clinical isolates recovered from Egyptian hospitals.
The study identified the presence of multidrug resistance genes such as AcrAB, mdtK, OmpK35, and OmpK36 in Klebsiella pneumoniae isolates. Additionally, virulence genes like fimH-1, mrkD, traT, entB, IucC, and irP-1 were detected, highlighting the complex nature of resistance and virulence in these isolates.
Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
The study identifies several AMR genes in the Nanosilver-resistant Proteus mirabilis strain SCDR1, including those conferring resistance to tetracycline, fluoroquinolones, sulfonamides, daptomycin, rifamycin, elfamycins, chloramphenicol, and amikacin.
Isolation and characterization of Uropathogenic Escherichia coli (UPEC) from red panda (Ailurus fulgens).
The study identified a Uropathogenic Escherichia coli (UPEC) strain isolated from a red panda that exhibited resistance to multiple antibiotics, including aminoglycosides, beta-lactams, and macrolides. The strain possessed 20 resistance genes, such as acra, acrb, mdte, mdtf, mdtn, mdto, mdtp, tolc, arna, baca, bcr, bl1_ec, emre, ksga, macb, mdfa, mdtg, mdth, mdtk, and mdtl, which contribute to multidrug resistance.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Salmonella isolated from waterfowl in 2002-2005 and 2018-2020 in Sichuan, China.
The study identified multiple AMR genes and mutations in Salmonella isolates from waterfowl in Sichuan, China, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance genes. Mutations in gyrA and gyrB were associated with nalidixic acid resistance.
Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
The study identified 26 chromosomal resistance genes in Salmonella Gallinarum strains, primarily encoding efflux pumps, and point mutations in gyrase genes (gyrA and gyrB) associated with quinolone resistance. The gyrB mutation S464T was frequently found in Colombian strains.
Better together-Salmonella biofilm-associated antibiotic resistance.
The study identifies several genes involved in Salmonella biofilm-associated antibiotic resistance, including efflux pumps, porins, and stress response proteins, highlighting their role in multidrug resistance and biofilm formation.
Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens.
The study identifies mutations in gyrB and upregulation of efflux pumps (acrAB, adeIJK, mdtK) as key mechanisms of resistance to GP6 in E. coli and A. baumannii.
The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant Salmonella Enteritidis strain 27A, including beta-lactamase blaTEM-194, aminoglycoside resistance genes aac(6)-Ib, aac(6)-If, aph(3”)-Ib, and aph(6)-Id, tetracycline resistance genes tetA, tetR, and tet34, and efflux pump genes acrA, acrB, tolC, oprM, mexE, mexF, macB, mdtG, mdtH, mdtL, mdtM, mdtK, rosA, emrA, emrR, ykkc, and vanRA.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
The study identified multiple AMR genes and mutations in extensive drug-resistant Salmonella Typhi isolates from Gujarat, India, including aph(3'')-Ib, aph(6)-Id, bla CTX-M, dfrA14, qnrS1, sul2, tet(A), mdtK, and gyrA mutations, contributing to resistance against various antibiotics such as tetracycline, fluoroquinolones, and beta-lactams.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
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