Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
major facilitator superfamily (MFS) antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D22A | - | Escherichia coli | phenicols | Reslit | Candidate | |
| F253Y | - | Escherichia coli | phenicols | Reslit | Candidate | |
| Y26A | - | Escherichia coli | phenicols | Reslit | Candidate | |
| Y57A | - | Escherichia coli | phenicols | Reslit | Candidate | |
| C116V | - | Escherichia coli | phenicols | Reslit | Candidate | |
| F253A | - | Escherichia coli | phenicols | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| mdtM | Card Database | 1 | - | Escherichia coli str. K-12 substr. MG1655 | - | - | U00096.3 | AAC77293.1 |
| MdtM | Card DatabaseReference Gene CatalogReslit | 14 | EFFLUX, beta lactams +22 | Escherichia coli str. K-12 substr. MG1655 +3 | Abuja, Nigeria, Balochistan, Pakistan, China, South Africa, Brazil, Europe|Russia, India, Finland, Europe, China|Thailand|USA|Spain|Norway|Japan|Vietnam|Hong Kong | 2013, 2016, 2022, 2023, 2024, 2025 | U00096.3 | AAC77293.1 |
The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds.
The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds.
Parallel Mapping of Antibiotic Resistance Alleles in Escherichia coli.
The study identified multiple genes and alleles associated with antibiotic resistance in Escherichia coli through a genome-scale barcoded library and enrichment analysis, highlighting the role of multi-drug resistance alleles in laboratory selections.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Virulence Factors and Antimicrobial Resistance of Uropathogenic Escherichia coli EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan.
The study identified multiple antimicrobial resistance genes in the E. coli EQ101 isolate, including genes involved in antibiotic efflux, inactivation, and drug replacement. Key resistance genes include TolC, emrR, evgA, qacEdelta1, H-NS, cpxA, mdtM, aadA5, mphA, CTX-M-15, sul1, and dfrA14.
The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis.
The study identified multiple antimicrobial resistance genes in the multidrug-resistant Salmonella Enteritidis strain 27A, including beta-lactamase blaTEM-194, aminoglycoside resistance genes aac(6)-Ib, aac(6)-If, aph(3”)-Ib, and aph(6)-Id, tetracycline resistance genes tetA, tetR, and tet34, and efflux pump genes acrA, acrB, tolC, oprM, mexE, mexF, macB, mdtG, mdtH, mdtL, mdtM, mdtK, rosA, emrA, emrR, ykkc, and vanRA.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics.
The study identified genomic resistance elements in historical clinical isolates, showing that resistance to antibiotics existed before their clinical introduction and increased in frequency and mobility after the age of antibiotics.
Ultrasound-Assisted Extraction: Unlocking the Antibacterial Potential of Coptis chinensis Franch. Against ESBL-Producing Enterobacterales.
The study identifies multiple beta-lactamase resistance genes in ESBL-PE strains, including blaCTX-M-14, blaCTX-M-1, blaCTX-M-3, blaCTX-M-15, blaCTX-M-65, blaSHV, blaTEM, blaEC, blaACC, blaCMY, blaACT, blaDHA, and efflux pump genes such as acrF, emrD, mdtM, silA, kdeA, oqxA, oqxB, arsB, oqxA10, oqxB5, oqxB19, arsA, and hugA, which contribute to multidrug resistance in these isolates.
Resistance evolution under potentiated sulphonamide pressure in Escherichia coli.
The study identified multiple antimicrobial resistance genes and mutations in E. coli under potentiated sulphonamide pressure, highlighting the role of efflux pumps and folate pathway modifications in resistance development.
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