mdtR

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MarR-type transcriptional regulator

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UniProt

Protein entries specific to mdtR

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Validation StatusCandidate

Overview

Validation Method: transformation experiments and northern blot analysis
Drug Classes: fusidic acid, novobiocin, streptomycin
Organisms: Bacillus subtilis
Papers: 1
Databases: Reslit

Papers1

Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.

PMID 19286808 · 2009

The study identifies and characterizes a novel multidrug resistance operon, mdtRP (yusOP), in Bacillus subtilis. The mdtR gene encodes a MarR-type transcriptional regulator, and the mdtP gene encodes a multidrug efflux transporter. Mutations in mdtR, such as Arg83 → Lys and Ala67 → Thr, lead to multidrug resistance by derepressing the mdtRP operon.

Gene Information

Gene Name: mdtR
Allele: mdtR
Encodes: MarR-type transcriptional regulator
Source Database: Reslit
Confers Resistance To: fusidic acidnovobiocinstreptomycin
Organisms Tested In: • Bacillus subtilis
Validation Method: transformation experiments and northern blot analysis

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mdtR

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mdtR

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