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efflux pump system

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UniProt

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Validation StatusCandidate

Overview

Validation Method: experimental data from efflux pump inhibition experiments
Drug Classes: fluoroquinolones, chloramphenicol florfenicol, tetracycline
Organisms: Salmonella enterica serovar Typhimurium
Papers: 1
Databases: Reslit

Papers1

Mathematical Modelling Highlights the Potential for Genetic Manipulation as an Adjuvant to Counter Efflux-Mediated MDR in Salmonella.

PMID 35380320 · 2022

The study highlights the role of RND efflux pump systems in mediating multidrug resistance (MDR) in Salmonella, particularly focusing on AcrAB, AcrEF, MdsAB, and MdtAB. Experimental data shows that overexpression of these efflux pumps leads to resistance against fluoroquinolones, chloramphenicol-florfenicol, and tetracyclines.

Gene Information

Gene Name: mdtab
Allele: MdtAB
Encodes: efflux pump system
Source Database: Reslit
Confers Resistance To: fluoroquinoloneschloramphenicol florfenicoltetracycline
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Validation Method: experimental data from efflux pump inhibition experiments

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