mdtbc

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RND efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mdtbc

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Validation StatusCandidate

Overview

Validation Method: genomic analysis
Drug Classes: cephalosporins, aztreonam, carbapenems, penicillin, aminoglycosides, rifamycins, fluoroquinolones, macrolides, nitroimidazoles, phenicols, tetracycline, aminocoumarin
Organisms: Salmonella Gallinarum
Geographic Location: Colombia
Papers: 1
Databases: Reslit

Papers1

Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.

PMID 37107581 · 2023

The study identified 26 chromosomal resistance genes in Salmonella Gallinarum strains, primarily encoding efflux pumps, and point mutations in gyrase genes (gyrA and gyrB) associated with quinolone resistance. The gyrB mutation S464T was frequently found in Colombian strains.

Gene Information

Gene Name: mdtbc
Allele: mdtBC
Encodes: RND efflux pump
Source Database: Reslit
Confers Resistance To: cephalosporinsaztreonamcarbapenemspenicillinaminoglycosidesrifamycinsfluoroquinolonesmacrolidesnitroimidazolesphenicolstetracyclineaminocoumarin
Organisms Tested In: • Salmonella Gallinarum
Geographic Location: Colombia
Validation Method: genomic analysis
Sequence Accession: PRJNA483415

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mdtbc

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mdtbc

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