Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA1
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MecA1 | Reference Gene CatalogResFinder DatabaseReslit | 10 | PIPERACILLIN+TAZOBACTAM, MEROPENEM +20 | Mammaliicoccus sciuri +4 | Northern Ghana, Somalia|Kenya|East Africa, Swiss Canton Tessin|various herds|Switzerland, Kenya, Africa, Europe | 1996, 2022, 2023, 2024, 2025 | AY820253.1 | AAX35723.1 |
| mecA1 | ResFinder Database | 1 | MEROPENEM, ERTAPENEM +12 | Mammaliicoccus sciuri | - | 2010 | AB547235, AY820253, Y13094, AB547236, AB547234 | - |
Origin and molecular evolution of the determinant of methicillin resistance in staphylococci., Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Prevalence of methicillin-resistant coagulase-negative staphylococci in Africa: a systematic review and meta-analysis.
The study identifies the prevalence of methicillin-resistant coagulase-negative staphylococci (MR-CoNS) in Africa, highlighting the presence of mecA, mecA1, and mecC genes in various species such as Staphylococcus epidermidis, Staphylococcus haemolyticus, and Mammaliicoccus sciuri.
Diversification of the Staphylococcal Cassette Chromosome Through Distinct Mechanisms of Horizontal Transfer.
The study identifies a wide distribution of mec genes across various Staphylococcaceae species, highlighting the diversity of SCC mec elements and their mechanisms of horizontal transfer.
Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri.
Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri.
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