mecD

methicillin resistant PBP2

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mecD

Browse AMR rules for mecD

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target replacement
Validation Method: expression in S. aureus and deletion of the mecD-containing island in M. caseolyticus
Drug Classes: penicillin, cephalosporins, carbapenems, oxacillin, temocillin, cefoxitin, cefotaxime, ceftazidime, cefepime, ertapenem, imipenem, meropenem, ceftobiprole, ceftaroline, PIPERACILLIN+TAZOBACTAM, MEROPENEM, ERTAPENEM, AMOXICILLIN, CEFOXITIN, IMIPENEM, CEFIXIME, CEFEPIME, AMPICILLIN+CLAVULANIC ACID, AMPICILLIN, CEFOTAXIME, CEFTAZIDIME, AMOXICILLIN+CLAVULANIC ACID, METHICILLIN, PIPERACILLIN, methicillin
Organisms: Macrococcoides caseolyticum, Macrococcus caseolyticus, Staphylococcus aureus
Geographic Location: England|Wales, Europe|Czech Republic|Switzerland, Switzerland|England|Wales, bovine|canine|Switzerland
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
mecD	Card DatabaseResFinder Database	2	MEROPENEM, ERTAPENEM +12	Macrococcoides caseolyticum	-	2017	KY013611.1	AQX82857.1
MecD	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	7	penicillin, cephalosporins +28	Macrococcus caseolyticus +2	bovine\|canine\|Switzerland, England\|Wales, Switzerland\|England\|Wales, Europe\|Czech Republic\|Switzerland	2017, 2018, 2019, 2025	KY013611\|NC_011999\|ABFA01000015.1\|JRHQ01000038.1\|ASAM01000028.1\|LXRS01000085.1\|WP_034289281\|WP_012656740\|WP_069304013\|KY013612\|KY013610\|KY013613	AQX82825.1

Papers4

1

Gene Information

Gene Name: mecD
Allele: mecD
Encodes: methicillin resistant PBP2
Source Database: Card Database
Mechanism: antibiotic target replacement
Organisms Tested In: • Macrococcoides caseolyticum
Sequence Accession: KY013611.1
Protein Accession: AQX82857.1
Notes: ARO:3004185

2

Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources.

PMID 28272476 · 2017

The study identifies a novel methicillin resistance gene, mecD, in Macrococcus caseolyticus strains from bovine and canine sources, which confers resistance to various β-lactam antibiotics, including anti-MRSA cephalosporins.

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: penicillin-binding protein 2a (PBP2a)
Source Database: Reslit
Confers Resistance To: penicillincephalosporinscarbapenemsoxacillintemocillincefoxitincefotaximeceftazidimecefepimeertapenemimipenemmeropenemceftobiproleceftaroline
Organisms Tested In: • Macrococcus caseolyticus
• Staphylococcus aureus
Geographic Location: bovine|canine|Switzerland
Validation Method: expression in S. aureus and deletion of the mecD-containing island in M. caseolyticus
Sequence Accession: KY013611|NC_011999|ABFA01000015.1|JRHQ01000038.1|ASAM01000028.1|LXRS01000085.1|WP_034289281|WP_012656740|WP_069304013|KY013612|KY013610|KY013613

3

Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources.

PMID 28272476 · 2017

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecD
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Macrococcoides caseolyticum
Sequence Accession: KY013610.1
Protein Accession: AQX82825.1
Notes: ARO:3004185

4

Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources.

PMID 28272476 · 2017

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecD
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Macrococcoides caseolyticum
Sequence Accession: KY013610.1
Protein Accession: AQX82825.1
Notes: ARO:3004185

5

Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources.

PMID 28272476 · 2017

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecD
Source Database: Card Database
Mechanism: Target modification
Confers Resistance To: PIPERACILLIN+TAZOBACTAMMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDMETHICILLINPIPERACILLIN
Organisms Tested In: • Macrococcoides caseolyticum
Sequence Accession: KY013610.1
Protein Accession: AQX82825.1
Notes: ARO:3004185

6

Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources.

PMID 28272476 · 2017

Gene Information

Gene Name: mecD
Allele: mecD
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: MEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIMEAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAMPIPERACILLIN
Organisms Tested In: • Macrococcoides caseolyticum
Sequence Accession: KY013611

7

Genome analysis of methicillin resistance in Macrococcus caseolyticus from dairy cattle in England and Wales.

PMID 29916803 · 2018

The study identifies mecB and mecD as the primary methicillin resistance determinants in 33 isolates of Macrococcus caseolyticus from dairy cattle in England and Wales.

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: methicillin resistance determinant
Source Database: Reslit
Confers Resistance To: methicillin
Organisms Tested In: • Macrococcus caseolyticus
Geographic Location: England|Wales
Validation Method: whole-genome sequencing and PCR
Sequence Accession: PRJNA420921|SRP126085

8

Typing of mecD Islands in Genetically Diverse Methicillin-Resistant Macrococcus caseolyticus Strains from Cattle.

PMID 31375493 · 2019

The study identifies the methicillin resistance gene mecD in genetically diverse methicillin-resistant Macrococcus caseolyticus strains from cattle, highlighting the presence of different mecD islands (McRI mecD -1, McRI mecD -2, and McRI mecD -3) and their distribution in various sequence types.

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: alternative penicillin-binding protein (PBP2a)
Source Database: Reslit
Confers Resistance To: methicillin
Organisms Tested In: • Macrococcus caseolyticus
Geographic Location: Switzerland|England|Wales
Validation Method: PCR and sequencing
Sequence Accession: MH671353

9

Evidence of in vitro mecB-mediated β-lactam antibiotic resistance transfer to Staphylococcus aureus from Macrococcus psychrotolerans sp. nov., a psychrophilic bacterium from food-producing animals and human clinical specimens.

PMID 40066988 · 2025

The study identifies the mecB gene carried on plasmids in Macrococcus psychrotolerans sp. nov. strains, which can be transferred to Staphylococcus aureus via conjugation, leading to β-lactam resistance.

Gene Information

Gene Name: mecD
Allele: MecD
Encodes: methicillin resistance gene
Source Database: Reslit
Confers Resistance To: methicillin
Organisms Tested In: • Macrococcus caseolyticus
Geographic Location: Europe|Czech Republic|Switzerland
Validation Method: experimental validation
Sequence Accession: CP079956.2|CP079957|CP079955|CP079956|CP079969|CP079980|CP080013|CP080023|PRJNA952914|PRJNA744395

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