Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
MFS-type efflux pump
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| MefA/E | Reslit | 1 | macrolides | Streptococcus pneumoniae | - | 2009 | - | - |
| mefA/E | Reslit | 8 | azithromycin, macrolides +1 | Streptococcus pneumoniae +5 | Ethiopia, Poland, Brazil, Germany, Iran, Europe, India | 2012, 2013, 2015, 2020, 2022, 2023 | MW295581|MW295576|MW295577|MW295582|MW295583|MW295586|MW295540|MW732927|MW732926|MW732929|MW732928 | - |
Efflux-mediated drug resistance in bacteria: an update.
The paper provides an updated overview of drug efflux pumps in bacteria, focusing on their structure, mechanisms, and roles in multidrug resistance. It highlights the importance of RND, MFS, MATE, SMR, and ABC transporters in efflux-mediated resistance.
The fitness cost of antibiotic resistance in Streptococcus pneumoniae: insight from the field.
The study identified mefA/E and ermB as the primary mechanisms of azithromycin resistance in Streptococcus pneumoniae and estimated their relative fitness costs.
The application of multiplex PCR to detect seven different DNA targets in group B streptococci.
The study developed a multiplex PCR method to detect seven DNA targets in Group B Streptococcus (GBS), including the macrolide resistance genes ermB and mefA/E.
Commensal Streptococcus agalactiae isolated from patients seen at University Hospital of Londrina, Paraná, Brazil: capsular types, genotyping, antimicrobial susceptibility and virulence determinants.
The study identified resistance to erythromycin and clindamycin in Streptococcus agalactiae isolates, primarily mediated by the ermA, ermB, and mefA/E genes.
Point-of-care multiplex PCR promises short turnaround times for microbial testing in hospital-acquired pneumonia--an observational pilot study in critical ill patients.
The study evaluated the performance of a point-of-care multiplex PCR system for detecting pathogens and antibiotic resistance markers in hospital-acquired pneumonia. The system showed significantly shorter turnaround times compared to conventional microbiological diagnostics, although its performance was limited by frequent test failures and non-concordant results.
Molecular characterization, antibiotic resistance pattern and capsular types of invasive Streptococcus pneumoniae isolated from clinical samples in Tehran, Iran.
The study identified the presence of ermB, mefA/E, and tetM genes in invasive Streptococcus pneumoniae isolates, which contribute to resistance against erythromycin and tetracycline.
Molecular Characteristic, Antibiotic Resistance, and Detection of Highly Immunoreactive Proteins of Group B Streptococcus Strains Isolated From Urinary Tract Infections in Polish Adults.
The study identified ermB and mefA/E genes as contributors to macrolide resistance in Group B Streptococcus (GBS) strains isolated from urinary tract infections in Polish adults. The ermB gene was present in all cMLS B phenotype strains, while mefA/E was found in three M phenotype strains.
Antibiotic resistance genes and molecular typing of Streptococcus agalactiae isolated from pregnant women.
The study identified several antibiotic resistance genes in Streptococcus agalactiae isolates from pregnant women, including ermB, mefA/E, ermTR, tetM, tetO, and aphA3, which confer resistance to macrolides, tetracyclines, and aminoglycosides.
Prevalence of macrolide-lincosamide-streptogramin resistant lactic acid bacteria isolated from food samples.
The study identifies the presence of MLS resistance genes ermB, mefA/E, msrA/B, and msrC in lactic acid bacteria isolated from food samples, highlighting the prevalence of macrolide-lincosamide-streptogramin resistance in LAB.
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