mepK

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endopeptidase

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Validation StatusCandidate

Overview

Validation Method: growth assay
Drug Classes: ceftriaxone
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli.

PMID 34382698 · 2021

The study identifies mepM and mepK as essential endopeptidases for β-lactam resistance mediated by the YcbB L,D-transpeptidase in Escherichia coli. These genes are crucial for hydrolyzing both 4→3 and 3→3 cross-links in peptidoglycan, facilitating resistance to ceftriaxone.

Gene Information

Gene Name: mepK
Allele: mepK
Encodes: endopeptidase
Source Database: Reslit
Confers Resistance To: ceftriaxone
Organisms Tested In: • Escherichia coli
Validation Method: growth assay
Sequence Accession: PRJNA748867

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mepK

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mepK

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