metF

View on PubMed

methionine synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to metF

AMR Rules

Browse AMR rules for metF

Validation StatusCandidate

Overview

Mechanism: mutation
Validation Method: experimental validation
Drug Classes: trimethoprim sulfamethoxazole
Organisms: Burkholderia pseudomallei
Geographic Location: Australia|Malaysia|Southeast Asia
Papers: 1
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q28P	-	-	-	trimethoprim sulfamethoxazole	Reslit	Candidate

Papers1

Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei.

PMID 33285499 · 2021

The study presents ARDaP, a new tool for comprehensive antimicrobial resistance (AMR) detection in Burkholderia pseudomallei. ARDaP accurately identifies various AMR determinants, including mutations in genes such as penA, bpeT, ptr1, metF, dut, bpsl3085, and amrR, which confer resistance to antibiotics like ceftazidime, meropenem, co-trimoxazole, and doxycycline.