metH

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B12-dependent methionine synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to metH

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: genetic mutagenesis, chemical complementation, metabolomic profiling
Drug Classes: sulfamethoxazole
Organisms: Mycobacterium smegmatis, Mycobacterium tuberculosis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium
Papers: 1
Databases: Reslit

Papers1

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs.

PMID 27760199 · 2016

The study identifies metH and cobIJ as critical genes involved in the methylfolate trap, which enhances susceptibility to sulfa drugs by impairing folate metabolism and leading to thymineless death in various bacterial species.

Gene Information

Gene Name: metH
Allele: metH
Encodes: B12-dependent methionine synthase
Source Database: Reslit
Confers Resistance To: sulfamethoxazole
Organisms Tested In: • Mycobacterium smegmatis
• Mycobacterium tuberculosis
• Escherichia coli
• Pseudomonas aeruginosa
• Salmonella typhimurium
Validation Method: genetic mutagenesis, chemical complementation, metabolomic profiling

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metH

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metH

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