Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
intergenic region near efflux pump regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| L45P | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| I46N | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L57P | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam|ofloxacinaztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | ReslitReference Gene Catalog | Candidate |
| L57R | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| T69I | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| I72N | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L75P | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| L75R | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| R83C | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam|ofloxacinaztreonam|carbenicillin|piperacillin tazobactam|meropenemaztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | ReslitReference Gene Catalog | Candidate |
| R91C | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| R91H | - | - | Pseudomonas aeruginosa | aztreonam|ofloxacin | Reslit | Candidate |
| V126E | mutations in regulators MexR, NalC, or NalD, reduced expression, increased efflux and resistance to certain beta-lactam antibiotics | Pseudomonas aeruginosa | fluoroquinolonesciprofloxacinfluoroquinolones|cephalosporins|aminoglycosides+8 more | Reslit | Candidate | |
| G155D | - | mutations in mexR ... cause upregulation of the efflux pumps and being associated with β-lactam resistance | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| G71E | - | - | Pseudomonas aeruginosa | aminoglycosides|fluoroquinolones|macrolides | Reslit | Candidate |
| S209R | - | - | Pseudomonas aeruginosa | aminoglycosides|fluoroquinolones|macrolides | Reslit | Candidate |
| H107P | - | - | Pseudomonas aeruginosa | aztreonam|ciprofloxacinfluoroquinolonesticarcillin|cefepime|aztreonam | Reslit | Candidate |
| P107S | - | - | - | fluoroquinolones | Reslit | Candidate |
| Q55P | - | increased MexAB efflux pump genes expression by altering MexR’s binding capacity | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| A164C | - | inactivating the OprD porin within the cellular membrane | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| H41A | - | - | Pseudomonas aeruginosa | norfloxacin | Reslit | Candidate |
| H116A | - | - | Pseudomonas aeruginosa | norfloxacin | Reslit | Candidate |
| C62S | - | - | Pseudomonas aeruginosa | norfloxacin | Reslit | Candidate |
| L13P | - | - | Pseudomonas aeruginosa | ceftazidime avibactam|meropenem | Reslit | Candidate |
| E41K | - | - | Pseudomonas aeruginosa | ciprofloxacin|tetracycline|phenicols|trimethoprim | Reslit | Candidate |
| A166V | - | mutations in mexR have resulted in loss of repressor activity (i.e., higher expression levels of mexAB) | Shewanella oneidensis | ciprofloxacin | Reslit | Candidate |
| A110T | - | reduced expression | Pseudomonas aeruginosa | ceftazidime|cefepime|ticarcillin|imipenem | Reslit | Candidate |
| K76Q | - | reduced expression | Pseudomonas aeruginosa | ceftazidime|cefepime|ticarcillin|imipenem | Reslit | Candidate |
| D89E | - | - | Pseudomonas aeruginosa | cefiderocol | Reslit | Candidate |
| A156T | - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate |
| G531D | - | - | Pseudomonas aeruginosa | aztreonam | Reslit | Candidate |
| E126V | - | - | Pseudomonas aeruginosa | ciprofloxacin|levofloxacin | Reslit | Candidate |
| I25T | - | - | Pseudomonas aeruginosa | ciprofloxacin|levofloxacin | Reslit | Candidate |
| I25N | - | - | Pseudomonas aeruginosa | ciprofloxacin|levofloxacin | Reslit | Candidate |
| Y3Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| Q31Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| P37R | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| Q49Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| L57Q | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| C62Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| R70Q | effux pump transcriptional repressor MexR, prevents MexR from binding to the intergenic region between mexR and mexAB-oprM operon | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactamaztreonam | Reference Gene CatalogReslit | Candidate | |
| D89N | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| Q94Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| G101E | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| Q106Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| E109Ter | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| T130P | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | aztreonam avibactam|carbapenems|cephalosporins|phenicols|vaborbactam | Reference Gene Catalog | Candidate |
| Q137H | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| Q137P | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| C138A | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| C138G | - | effux pump transcriptional repressor MexR | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| - | interferes with the regular transcription of the efflux component MexA | Pseudomonas aeruginosa | carbenicillin|cef|ciprofloxacin | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | carbapenems|cephalosporins|fluoroquinolones | Reslit | Candidate |
The Genomic Basis of Rapid Adaptation to Antibiotic Combination Therapy in Pseudomonas aeruginosa.
The study identifies variants in efflux regulatory systems, including mexR, nalC, and their intergenic regions, as key mechanisms of resistance in Pseudomonas aeruginosa under antibiotic combination therapies.
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