Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
regulator of the expression of the genes coding for the MexEF-OprN efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T11N | - | - | - | tobramycin | Reslit | Candidate |
| V130F | loss of function | Pseudomonas aeruginosa | aminoglycosides|colistin | Reslit | Candidate | |
| G207S | - | loss of function | Pseudomonas aeruginosa | aminoglycosides|colistin | Reslit | Candidate |
| R40H | - | - | Pseudomonas aeruginosa | fluoroquinolones|cephalosporins | Reslit | Candidate |
| P170L | - | - | Pseudomonas aeruginosa | tobramycin | Reslit | Candidate |
| L149Q | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| G827D | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| L722Q | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| T469P | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| L368P | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| Y431S | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| E502K | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| D176A | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| P712T | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| M1I | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| Q209* | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| T529P | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| V389A | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| E123K | - | - | Pseudomonas aeruginosa | phenicols | Reslit | Candidate |
| F34L | - | - | Pseudomonas aeruginosa | phenicols|trimethoprim sulfamethoxazole | Reslit | Candidate |
| G163D | - | - | - | colistin | Reslit | Candidate |
| A678V | - | - | Pseudomonas aeruginosa | ceftazidime avibactam|ceftolozane tazobactam | Reslit | Candidate |
| G195D | - | - | Pseudomonas aeruginosa | piperacillin tazobactam|ceftazidime|cefepime|meropenem|imipenem|tobramycin|ciprofloxacin | Reslit | Candidate |
| G300S | - | LysR substrate-binding domain-containing protein MexT | Pseudomonas aeruginosa | phenicols|quinolones|trimethoprim | Reference Gene Catalog | Candidate |
| - | - | Pseudomonas aeruginosa | fluoroquinolones | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | ciprofloxacin|imipenem | Reslit | Candidate |
Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.
Mutations in mexT bypass the stringent response dependency of virulence in Pseudomonas aeruginosa.
Analysis of intrahospital and global dissemination and resistome dynamics of NDM-1-producing ST773 Pseudomonas aeruginosa high-risk clone.
mutation leads to overexpression of MexEF-OprN efflux pump
Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance.
Selection for increased quorum-sensing cooperation in Pseudomonas aeruginosa through the shut-down of a drug resistance pump.
Mutations in mexT lead to reduced MexEF-OprN activity, resulting in decreased resistance to chloramphenicol.
Within-Host Evolution of the Dutch High-Prevalent Pseudomonas aeruginosa Clone ST406 during Chronic Colonization of a Patient with Cystic Fibrosis.
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
Molecular characterization of clinically isolated Pseudomonas aeruginosa with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021.
Monitoring of Pseudomonas aeruginosa mutational resistome dynamics using an enrichment panel for direct sequencing of clinical samples.
Detected in ST175 isolate.
Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa.
mexT
Exploring the success of Brazilian endemic clone Pseudomonas aeruginosa ST277 and its association with the CRISPR-Cas system type I-C.
Role of the MexEF-OprN Efflux System in Low-Level Resistance of Pseudomonas aeruginosa to Ciprofloxacin.
mutations in mexT lead to overexpression of mexEF-oprN