Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation.
The study identifies several AMR genes and mutations in multidrug-resistant Pseudomonas aeruginosa strains, including beta-lactamases, efflux pumps, and mutations in the pmrAB system, which contribute to resistance against polymyxins and other antibiotics.
Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence.
Mutations in mexR and mexEF efflux pump genes increase P. aeruginosa virulence. mexR mutations lead to overexpression of the MexAB-OprM efflux pump, while mexEF mutations result in loss-of-function of the mexEF-oprN efflux pump, both contributing to increased virulence in mouse infection models.
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