Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane lipoprotein
Overview
Phenotypic and Multi-Omics Characterization of Escherichia coli K-12 Adapted to Chlorhexidine Identifies the Role of MlaA and Other Cell Envelope Alterations Regulated by Stress Inducible Pathways in CHX Resistance.
The study identifies mlaA as a key gene involved in chlorhexidine (CHX) resistance in Escherichia coli K-12, with mutations in mlaA leading to CHX resistance. Complementation of mlaA reverted the CHX-resistant phenotype to wild-type.
Sub-Inhibitory Concentrations of Chlorhexidine Induce Resistance to Chlorhexidine and Decrease Antibiotic Susceptibility in Neisseria gonorrhoeae.
Exposure to sub-lethal chlorhexidine concentrations induced resistance to chlorhexidine and cross-resistance to other antibiotics in Neisseria gonorrhoeae. Mutations in norM, mtrR, and mlaA were associated with increased chlorhexidine resistance.
Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps.
The study characterizes the roles of mlaA, acrB, ompCF, and aceI in chlorhexidine resistance in E. coli through gene deletion mutants and plasmid transformants, demonstrating that these genes contribute to increased MIC values and altered membrane permeability.
No comments yet. Be the first to comment!