mlaC

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ABC transporter periplasmic binding protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mlaC

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: disk diffusion assay and MIC testing
Drug Classes: tetracycline, doxycycline, tigecycline, phenicols, azithromycin, clarithromycin, erythromycin, ciprofloxacin, levofloxacin, rifampicin
Organisms: Burkholderia cenocepacia, Burkholderia dolosa
Papers: 1
Databases: Reslit

Papers1

The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components.

PMID 29986943 · 2018

The Mla pathway is essential for the intrinsic resistance of Burkholderia cepacia complex species to various antibiotics, including tetracyclines, chloramphenicol, macrolides, fluoroquinolones, and rifampin.

Gene Information

Gene Name: mlaC
Allele: mlaC
Encodes: ABC transporter periplasmic binding protein
Source Database: Reslit
Confers Resistance To: tetracyclinedoxycyclinetigecyclinephenicolsazithromycinclarithromycinerythromycinciprofloxacinlevofloxacinrifampicin
Organisms Tested In: • Burkholderia cenocepacia
• Burkholderia dolosa
Validation Method: disk diffusion assay and MIC testing

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mlaC

Gene Information

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mlaC

Gene Information