mlaF

ATP-binding cassette (ABC) antibiotic efflux pump

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: transformation and MIC testing
Drug Classes: colistin, polymyxin b
Organisms: Escherichia coli, Aeromonas hydrophila, Vibrio cholerae O139 MO10
Geographic Location: China, Global
Papers: 2
Databases: Card DatabaseReslit

Papers2

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ATP-binding cassette (ABC) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Escherichia coli
Sequence Accession: LR730402.1
Protein Accession: VWQ04088.1
Notes: ARO:3005041

Various Novel Colistin Resistance Mechanisms Interact To Facilitate Adaptation of Aeromonas hydrophila to Complex Colistin Environments.

PMID 33903105 · 2021

The study identifies mlaF D173A, arnBCADTEF operon, and gene 3832 as key contributors to colistin resistance in Aeromonas hydrophila, along with the involvement of the EnvZ/OmpR two-component system and the PhoP/PhoQ system in lipid A modification.

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ABC transporter ATP-binding protein
Source Database: Reslit
Confers Resistance To: colistin
Organisms Tested In: • Aeromonas hydrophila
Geographic Location: China
Validation Method: transformation and MIC testing
Sequence Accession: CP038463|CP038464|CP038465|CP038466|MN862663|MN862664|MN862666|MN885538|MT812950

Mechanisms of Polymyxin B Resistance in Vibrio cholerae Variants Through Membrane Vesicle Production and Genetic Mutations

PMID 36090081 · 2023

Mutations in vacJ, mlaF, dacB, and ihfA contribute to polymyxin B resistance in Vibrio cholerae variants through hypervesiculation and membrane remodeling.

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ATPase of the Mla pathway
Source Database: Reslit
Mechanism: loss of function
Confers Resistance To: polymyxin b
Organisms Tested In: • Vibrio cholerae O139 MO10
Geographic Location: Global
Validation Method: genomic sequencing and complementation assay
Sequence Accession: NCBI Accession Number 1|NCBI Accession Number 2

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mlaF

ATP-binding cassette (ABC) antibiotic efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mlaF

AMR Rules

Browse AMR rules for mlaF

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: transformation and MIC testing
Drug Classes: colistin, polymyxin b
Organisms: Escherichia coli, Aeromonas hydrophila, Vibrio cholerae O139 MO10
Geographic Location: China, Global
Papers: 2
Databases: Card DatabaseReslit

Papers2

PMID N/A

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ATP-binding cassette (ABC) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Escherichia coli
Sequence Accession: LR730402.1
Protein Accession: VWQ04088.1
Notes: ARO:3005041

Various Novel Colistin Resistance Mechanisms Interact To Facilitate Adaptation of Aeromonas hydrophila to Complex Colistin Environments.

PMID 33903105 · 2021

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ABC transporter ATP-binding protein
Source Database: Reslit
Confers Resistance To: colistin
Organisms Tested In: • Aeromonas hydrophila
Geographic Location: China
Validation Method: transformation and MIC testing
Sequence Accession: CP038463|CP038464|CP038465|CP038466|MN862663|MN862664|MN862666|MN885538|MT812950

Mechanisms of Polymyxin B Resistance in Vibrio cholerae Variants Through Membrane Vesicle Production and Genetic Mutations

PMID 36090081 · 2023

Mutations in vacJ, mlaF, dacB, and ihfA contribute to polymyxin B resistance in Vibrio cholerae variants through hypervesiculation and membrane remodeling.

Gene Information

Gene Name: mlaF
Allele: mlaF
Encodes: ATPase of the Mla pathway
Source Database: Reslit
Mechanism: loss of function
Confers Resistance To: polymyxin b
Organisms Tested In: • Vibrio cholerae O139 MO10
Geographic Location: Global
Validation Method: genomic sequencing and complementation assay
Sequence Accession: NCBI Accession Number 1|NCBI Accession Number 2

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mlaF

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mlaF

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