mltF

View on PubMed

lytic transglycosylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mltF

AMR Rules

Browse AMR rules for mltF

Validation StatusCandidate

Overview

Validation Method: transcriptional upregulation in polymyxin-dependent strains
Drug Classes: colistin
Organisms: Acinetobacter baumannii
Geographic Location: Global
Papers: 1
Databases: Reslit

Papers1

Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance.

PMID 32775156 · 2020

The study identifies lpxC and katG mutations as critical for polymyxin dependence in Acinetobacter baumannii, highlighting the importance of lipid A biosynthesis and oxidative stress response in this unique resistance mechanism.

Gene Information

Gene Name: mltF
Allele: mltF
Encodes: lytic transglycosylase
Source Database: Reslit
Confers Resistance To: colistin
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Global
Validation Method: transcriptional upregulation in polymyxin-dependent strains
Sequence Accession: NCBI:CP041022|NCBI:CP041023|NCBI:ABC123456

Comments (0)

No comments yet. Be the first to comment!

mltF

Gene Information

Browse AMR Genes

mltF

Gene Information