mltG

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Endolytic murein transglycosylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mltG

AMR Rules

Browse AMR rules for mltG

Validation StatusCandidate

Overview

Validation Method: deletion mutant analysis
Drug Classes: meropenem, cefepime, ceftriaxone, beta lactams, penicillin
Organisms: Pseudomonas aeruginosa, Enterococcus faecalis, Corynebacterium striatum, Neisseria subflava
Papers: 4
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T20A	-	-	Enterococcus faecalis	ceftriaxone	Reslit	Candidate
T102A	-	-	Corynebacterium striatum	beta lactams	Reslit	Candidate
P293L	-	-	Neisseria subflava	penicillin	Reslit	Candidate

Papers4

Identification of Drug Resistance Determinants in a Clinical Isolate of Pseudomonas aeruginosa by High-Density Transposon Mutagenesis.

PMID 31818817 · 2020

The study identifies several nonessential genes involved in β-lactam resistance in Pseudomonas aeruginosa, including ampC, mltG, mepM1, amgK, and ygfB, which contribute to the induction of ampC expression and resistance against meropenem and cefepime.

Gene Information

Gene Name: mltG
Allele: mltG
Encodes: Endolytic murein transglycosylase
Source Database: Reslit
Confers Resistance To: meropenemcefepime
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: deletion mutant analysis
Sequence Accession: PRJEB32702

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Protein Change

Nucleotide Change

Mechanism

Organism

Resistance To

Database

Validation Status

T20A

Enterococcus faecalis

ceftriaxone

Reslit

Candidate

T102A

Corynebacterium striatum

beta lactams

Reslit

Candidate

P293L

Neisseria subflava

penicillin

Reslit

Candidate

mltG

Mutations

Gene Information

Browse AMR Genes

mltG

Mutations

Gene Information