mltf2

View on PubMed

lytic transglycosylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to mltf2

AMR Rules

Browse AMR rules for mltf2

Validation StatusCandidate

Overview

Mechanism: increased β-lactam MICs
Validation Method: MIC assays
Drug Classes: piperacillin, cefotaxime
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa.

PMID 26374494 · 2015

The study identifies that loss of specific lytic transglycosylases (slt, mltB, and sltB1) in Pseudomonas aeruginosa increases β-lactam sensitivity, indicating their role in maintaining outer membrane integrity and reducing antibiotic resistance.

Gene Information

Gene Name: mltf2
Allele: mltF2
Encodes: lytic transglycosylase
Source Database: Reslit
Mechanism: increased β-lactam MICs
Confers Resistance To: piperacillincefotaxime
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: MIC assays

Comments (0)

No comments yet. Be the first to comment!

mltf2

Gene Information

Browse AMR Genes

mltf2

Gene Information